Richard R Tidwell Selected Research

African Trypanosomiasis (Nagana)

1/2017	Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis.
1/2017	In Vitro, Ex Vivo, and In Vivo Activities of Diamidines against Trypanosoma congolense and Trypanosoma vivax.
2/2015	Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys.
8/2014	In vitro and in vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness.
1/2014	CYP1A1 and CYP1B1-mediated biotransformation of the antitrypanosomal methamidoxime prodrug DB844 forms novel metabolites through intramolecular rearrangement.
2/2013	Compartmental and enzyme kinetic modeling to elucidate the biotransformation pathway of a centrally acting antitrypanosomal prodrug.
1/2012	Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis.
8/2010	Diamidines for human African trypanosomiasis.
8/2007	Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes.
11/2006	Roles for the Trypanosoma brucei P2 transporter in DB75 uptake and resistance.

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Richard R Tidwell Research Topics

Disease

13	African Trypanosomiasis (Nagana) 01/2017 - 04/2004
5	Trypanosomiasis 02/2016 - 06/2006
3	Body Weight (Weight, Body) 07/2014 - 12/2009
3	Visceral Leishmaniasis (Kala Azar) 12/2010 - 08/2009
3	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 01/2008 - 04/2004
2	Cardiac Arrhythmias (Arrythmia) 01/2017 - 07/2013
2	Infections 07/2014 - 01/2012
2	Parasitemia 07/2014 - 08/2009
2	Malaria 05/2009 - 10/2004
2	Acquired Immunodeficiency Syndrome (AIDS) 07/2004 - 07/2002
1	Glomerulonephritis 02/2016
1	Central Nervous System Infections (Central Nervous System Infection) 08/2014
1	Parasitic Diseases (Parasitic Disease) 07/2011
1	Leishmaniasis 04/2007
1	Pneumonia (Pneumonitis) 10/2004

Drug/Important Bio-Agent (IBA)

11	Pentamidine (NebuPent)FDA LinkGeneric 02/2016 - 06/2006
7	ProdrugsIBA 02/2015 - 07/2004
5	pafuramidineIBA 02/2016 - 07/2004
5	furamidine (DB75)IBA 11/2006 - 04/2004
4	furanIBA 01/2014 - 05/2009
3	Amphotericin B (Amphotericin)FDA LinkGeneric 12/2010 - 08/2009
2	N- methoxy- 6- (5- (4- (N- methoxyamidino)phenyl)furan- 2- yl)nicotinamidineIBA 01/2014 - 01/2012
2	DiminazeneIBA 07/2011 - 12/2009
1	Ion Channels (Ion Channel)IBA 01/2017
1	isometamidium chloride (ISMM)IBA 01/2017
1	homidium chlorideIBA 01/2017
1	AminesIBA 01/2017
1	Urea (Carbamide)FDA LinkGeneric 01/2017
1	diminazene aceturateIBA 01/2017
1	CPD0905IBA 08/2014
1	benzonidazole (benznidazole)IBA 07/2014
1	Proteins (Proteins, Gene)FDA Link 07/2013
1	NifurtimoxIBA 01/2012
1	Eflornithine (Ornidyl)FDA Link 01/2012
1	diphenyl (biphenyl)IBA 07/2011
1	liposomal amphotericin B FDA Link 03/2010
1	Suramin (Suramin Sodium)IBA 12/2009
1	quinapyramineIBA 12/2009
1	Melarsoprol (Mel B)IBA 11/2008
1	CarbamatesIBA 01/2008
1	amidoximeIBA 11/2006
1	Anti-Infective Agents (Microbicides)IBA 04/2004
1	Lamivudine (Epivir)FDA Link 07/2002
1	amprenavir (Agenerase)FDA Link 07/2002
1	NucleosidesIBA 07/2002
1	Zidovudine (Retrovir)FDA LinkGeneric 07/2002

Therapy/Procedure

2	Drug Therapy (Chemotherapy) 02/2015 - 04/2007
2	Therapeutics 01/2012 - 08/2009
1	Oral Administration 08/2009